The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies

Research output: Contribution to journal › Review › Research › peer-review

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The relationship between genetic risk variants with brain structure and function in bipolar disorder : A systematic review of genetic-neuroimaging studies. / Pereira, Licia P; Köhler, Cristiano A; de Sousa, Rafael T; Solmi, Marco; de Freitas, Bárbara P; Fornaro, Michele; Machado-Vieira, Rodrigo; Miskowiak, Kamilla W; Vieta, Eduard; Veronese, Nicola; Stubbs, Brendon; Carvalho, André F.

In: Neuroscience & Biobehavioral Reviews, Vol. 79, 08.2017, p. 87-109.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Pereira, LP, Köhler, CA, de Sousa, RT, Solmi, M, de Freitas, BP, Fornaro, M, Machado-Vieira, R, Miskowiak, KW, Vieta, E, Veronese, N, Stubbs, B & Carvalho, AF 2017, 'The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies', Neuroscience & Biobehavioral Reviews, vol. 79, pp. 87-109. https://doi.org/10.1016/j.neubiorev.2017.05.002

APA

Pereira, L. P., Köhler, C. A., de Sousa, R. T., Solmi, M., de Freitas, B. P., Fornaro, M., Machado-Vieira, R., Miskowiak, K. W., Vieta, E., Veronese, N., Stubbs, B., & Carvalho, A. F. (2017). The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies. Neuroscience & Biobehavioral Reviews, 79, 87-109. https://doi.org/10.1016/j.neubiorev.2017.05.002

Vancouver

Pereira LP, Köhler CA, de Sousa RT, Solmi M, de Freitas BP, Fornaro M et al. The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies. Neuroscience & Biobehavioral Reviews. 2017 Aug;79:87-109. https://doi.org/10.1016/j.neubiorev.2017.05.002

Author

Pereira, Licia P ; Köhler, Cristiano A ; de Sousa, Rafael T ; Solmi, Marco ; de Freitas, Bárbara P ; Fornaro, Michele ; Machado-Vieira, Rodrigo ; Miskowiak, Kamilla W ; Vieta, Eduard ; Veronese, Nicola ; Stubbs, Brendon ; Carvalho, André F. / The relationship between genetic risk variants with brain structure and function in bipolar disorder : A systematic review of genetic-neuroimaging studies. In: Neuroscience & Biobehavioral Reviews. 2017 ; Vol. 79. pp. 87-109.

Bibtex

@article{ccd9d944391d43cf8addbdd2bfebaa56,
title = "The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies",
abstract = "Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N=2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach. Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers. This review underscores the potential of gene-neuroimaging paradigms to provide mechanistic insights for BD. However, this systematic review found a single replicated finding. Suggestions to improve the reproducibility of this emerging field are provided, including the adoption of a trans-diagnostic approach.",
keywords = "Faculty of Social Sciences, Bipolar disorder, Genetic polymorphisms, Neuroimaging, Magnetic resonance imaging, Functional MRI, Diffusion tensor imagingvoxel based morphometry",
author = "Pereira, {Licia P} and K{\"o}hler, {Cristiano A} and {de Sousa}, {Rafael T} and Marco Solmi and {de Freitas}, {B{\'a}rbara P} and Michele Fornaro and Rodrigo Machado-Vieira and Miskowiak, {Kamilla W} and Eduard Vieta and Nicola Veronese and Brendon Stubbs and Carvalho, {Andr{\'e} F}",
note = "Copyright {\textcopyright} 2017 Elsevier Ltd. All rights reserved.",
year = "2017",
month = aug,
doi = "10.1016/j.neubiorev.2017.05.002",
language = "English",
volume = "79",
pages = "87--109",
journal = "Neuroscience & Biobehavioral Reviews",
issn = "0149-7634",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - The relationship between genetic risk variants with brain structure and function in bipolar disorder

T2 - A systematic review of genetic-neuroimaging studies

AU - Pereira, Licia P

AU - Köhler, Cristiano A

AU - de Sousa, Rafael T

AU - Solmi, Marco

AU - de Freitas, Bárbara P

AU - Fornaro, Michele

AU - Machado-Vieira, Rodrigo

AU - Miskowiak, Kamilla W

AU - Vieta, Eduard

AU - Veronese, Nicola

AU - Stubbs, Brendon

AU - Carvalho, André F

N1 - Copyright © 2017 Elsevier Ltd. All rights reserved.

PY - 2017/8

Y1 - 2017/8

N2 - Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N=2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach. Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers. This review underscores the potential of gene-neuroimaging paradigms to provide mechanistic insights for BD. However, this systematic review found a single replicated finding. Suggestions to improve the reproducibility of this emerging field are provided, including the adoption of a trans-diagnostic approach.

AB - Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N=2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach. Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers. This review underscores the potential of gene-neuroimaging paradigms to provide mechanistic insights for BD. However, this systematic review found a single replicated finding. Suggestions to improve the reproducibility of this emerging field are provided, including the adoption of a trans-diagnostic approach.

KW - Faculty of Social Sciences

KW - Bipolar disorder

KW - Genetic polymorphisms

KW - Neuroimaging

KW - Magnetic resonance imaging

KW - Functional MRI

KW - Diffusion tensor imagingvoxel based morphometry

U2 - 10.1016/j.neubiorev.2017.05.002

DO - 10.1016/j.neubiorev.2017.05.002

M3 - Review

C2 - 28479278

VL - 79

SP - 87

EP - 109

JO - Neuroscience & Biobehavioral Reviews

JF - Neuroscience & Biobehavioral Reviews

SN - 0149-7634

ER -

ID: 184209182