Determination of sulfadiazine in phosphate- and DOC-rich agricultural drainage water using solid-phase extraction followed by liquid chromatography-tandem mass spectrometry

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Determination of sulfadiazine in phosphate- and DOC-rich agricultural drainage water using solid-phase extraction followed by liquid chromatography-tandem mass spectrometry. / Bouyou, P.A. Léon; Weisser, Johan Juhl; Strobel, Bjarne W.

In: Analytical and Bioanalytical Chemistry, Vol. 406, 2014, p. 5019-5030.

Research output: Contribution to journalJournal article

Harvard

Bouyou, PAL, Weisser, JJ & Strobel, BW 2014, 'Determination of sulfadiazine in phosphate- and DOC-rich agricultural drainage water using solid-phase extraction followed by liquid chromatography-tandem mass spectrometry', Analytical and Bioanalytical Chemistry, vol. 406, pp. 5019-5030. https://doi.org/10.1007/s00216-014-7921-6

APA

Bouyou, P. A. L., Weisser, J. J., & Strobel, B. W. (2014). Determination of sulfadiazine in phosphate- and DOC-rich agricultural drainage water using solid-phase extraction followed by liquid chromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry, 406, 5019-5030. https://doi.org/10.1007/s00216-014-7921-6

Vancouver

Bouyou PAL, Weisser JJ, Strobel BW. Determination of sulfadiazine in phosphate- and DOC-rich agricultural drainage water using solid-phase extraction followed by liquid chromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry. 2014;406:5019-5030. https://doi.org/10.1007/s00216-014-7921-6

Author

Bouyou, P.A. Léon ; Weisser, Johan Juhl ; Strobel, Bjarne W. / Determination of sulfadiazine in phosphate- and DOC-rich agricultural drainage water using solid-phase extraction followed by liquid chromatography-tandem mass spectrometry. In: Analytical and Bioanalytical Chemistry. 2014 ; Vol. 406. pp. 5019-5030.

Bibtex

@article{749505291d2d412ea0a18f7b4d9495fb,
title = "Determination of sulfadiazine in phosphate- and DOC-rich agricultural drainage water using solid-phase extraction followed by liquid chromatography-tandem mass spectrometry",
abstract = "Trace levels of the veterinary antibiotic compound sulfadiazine (SDZ) can be determined in agricultural drainage water samples with this new method. Optimized sample pretreatment and solid-phase extraction was combined with liquid chromatography coupled to tandem mass spectrometry (SPE LC-MS/MS) using positive electrospray ionization. The linear dynamic range for the LC-MS/MS was assessed from 5 μg/L to 25 mg/L with a 15-point calibration curve displaying a coefficient of correlation r 2 = 0.9915. Agricultural drainage water spiked at a concentration of 25 ng/L gave recoveries between 63 and 98 {\%} (relative standard deviation 15 {\%}), while at 10 ng/L, it showed a lower recovery of 32 {\%} (relative standard deviation 47 {\%}). The final SPE LC-MS/MS method had a limit of detection (LOD)Method and a limit of quantification (LOQ)Method of 7.5 and 23 ng/L agricultural drainage water, respectively. Determination of SDZ, spiked at a realistic concentration of 50 μg/L, in artificial drainage water (ADW) containing common and high levels of phosphate (0.05, 0.5, and 5 mg/L) gave recoveries between 70 and 92 {\%} (relative standard deviation 7.4–12.9 {\%}). Analysis of the same realistic concentration of SDZ in ADW, spiked with common and high levels of dissolved organic carbon (2, 6, and 15 mg/L) confirmed the possible adaptation of a tandem solid-phase extraction (strong anion exchange (SAX)-hydrophilic-lipophilic balance (HLB)) followed by liquid chromatography-tandem mass spectrometry methodology. Recoveries obtained ranged from 104 to 109 {\%} (relative standard deviation 2.8–5.2 {\%}). The new methods enable determination of the veterinary antibiotic compound SDZ in agricultural drainage water from field experiments and monitoring schemes for phosphate- and dissolved organic carbon (DOC)-rich water samples in intensive farming areas.",
keywords = "Soil chemistry, sulfadiazine, UPLC-ESI-MS/MS, DRAINAGE SYSTEMS, Water Pollutants, Chemical, analytical chemistry, ???Milj{\o}venlig afgr{\o}deproduktion???, Phosphate, Environmental Chemistry",
author = "Bouyou, {P.A. L{\'e}on} and Weisser, {Johan Juhl} and Strobel, {Bjarne W.}",
year = "2014",
doi = "10.1007/s00216-014-7921-6",
language = "English",
volume = "406",
pages = "5019--5030",
journal = "Analytical and Bioanalytical Chemistry",
issn = "1618-2642",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Determination of sulfadiazine in phosphate- and DOC-rich agricultural drainage water using solid-phase extraction followed by liquid chromatography-tandem mass spectrometry

AU - Bouyou, P.A. Léon

AU - Weisser, Johan Juhl

AU - Strobel, Bjarne W.

PY - 2014

Y1 - 2014

N2 - Trace levels of the veterinary antibiotic compound sulfadiazine (SDZ) can be determined in agricultural drainage water samples with this new method. Optimized sample pretreatment and solid-phase extraction was combined with liquid chromatography coupled to tandem mass spectrometry (SPE LC-MS/MS) using positive electrospray ionization. The linear dynamic range for the LC-MS/MS was assessed from 5 μg/L to 25 mg/L with a 15-point calibration curve displaying a coefficient of correlation r 2 = 0.9915. Agricultural drainage water spiked at a concentration of 25 ng/L gave recoveries between 63 and 98 % (relative standard deviation 15 %), while at 10 ng/L, it showed a lower recovery of 32 % (relative standard deviation 47 %). The final SPE LC-MS/MS method had a limit of detection (LOD)Method and a limit of quantification (LOQ)Method of 7.5 and 23 ng/L agricultural drainage water, respectively. Determination of SDZ, spiked at a realistic concentration of 50 μg/L, in artificial drainage water (ADW) containing common and high levels of phosphate (0.05, 0.5, and 5 mg/L) gave recoveries between 70 and 92 % (relative standard deviation 7.4–12.9 %). Analysis of the same realistic concentration of SDZ in ADW, spiked with common and high levels of dissolved organic carbon (2, 6, and 15 mg/L) confirmed the possible adaptation of a tandem solid-phase extraction (strong anion exchange (SAX)-hydrophilic-lipophilic balance (HLB)) followed by liquid chromatography-tandem mass spectrometry methodology. Recoveries obtained ranged from 104 to 109 % (relative standard deviation 2.8–5.2 %). The new methods enable determination of the veterinary antibiotic compound SDZ in agricultural drainage water from field experiments and monitoring schemes for phosphate- and dissolved organic carbon (DOC)-rich water samples in intensive farming areas.

AB - Trace levels of the veterinary antibiotic compound sulfadiazine (SDZ) can be determined in agricultural drainage water samples with this new method. Optimized sample pretreatment and solid-phase extraction was combined with liquid chromatography coupled to tandem mass spectrometry (SPE LC-MS/MS) using positive electrospray ionization. The linear dynamic range for the LC-MS/MS was assessed from 5 μg/L to 25 mg/L with a 15-point calibration curve displaying a coefficient of correlation r 2 = 0.9915. Agricultural drainage water spiked at a concentration of 25 ng/L gave recoveries between 63 and 98 % (relative standard deviation 15 %), while at 10 ng/L, it showed a lower recovery of 32 % (relative standard deviation 47 %). The final SPE LC-MS/MS method had a limit of detection (LOD)Method and a limit of quantification (LOQ)Method of 7.5 and 23 ng/L agricultural drainage water, respectively. Determination of SDZ, spiked at a realistic concentration of 50 μg/L, in artificial drainage water (ADW) containing common and high levels of phosphate (0.05, 0.5, and 5 mg/L) gave recoveries between 70 and 92 % (relative standard deviation 7.4–12.9 %). Analysis of the same realistic concentration of SDZ in ADW, spiked with common and high levels of dissolved organic carbon (2, 6, and 15 mg/L) confirmed the possible adaptation of a tandem solid-phase extraction (strong anion exchange (SAX)-hydrophilic-lipophilic balance (HLB)) followed by liquid chromatography-tandem mass spectrometry methodology. Recoveries obtained ranged from 104 to 109 % (relative standard deviation 2.8–5.2 %). The new methods enable determination of the veterinary antibiotic compound SDZ in agricultural drainage water from field experiments and monitoring schemes for phosphate- and dissolved organic carbon (DOC)-rich water samples in intensive farming areas.

KW - Soil chemistry

KW - sulfadiazine

KW - UPLC-ESI-MS/MS

KW - DRAINAGE SYSTEMS

KW - Water Pollutants, Chemical

KW - analytical chemistry

KW - ???Miljøvenlig afgrødeproduktion???

KW - Phosphate

KW - Environmental Chemistry

U2 - 10.1007/s00216-014-7921-6

DO - 10.1007/s00216-014-7921-6

M3 - Journal article

C2 - 24912991

VL - 406

SP - 5019

EP - 5030

JO - Analytical and Bioanalytical Chemistry

JF - Analytical and Bioanalytical Chemistry

SN - 1618-2642

ER -

ID: 135272587