Effect of vitamin D on inflammatory and clinical outcomes in patients with rheumatoid arthritis (RA): A systematic review and dose-response meta-analysis of randomized controlled trials
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Effect of vitamin D on inflammatory and clinical outcomes in patients with rheumatoid arthritis (RA) : A systematic review and dose-response meta-analysis of randomized controlled trials. / Al-Saoodi, Hagir; Kolahdooz, Fariba; Andersen, Jens Rikardt; Jalili, Mahsa.
In: Nutrition Reviews, Vol. 82, No. 5, 2024, p. 600–611.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Effect of vitamin D on inflammatory and clinical outcomes in patients with rheumatoid arthritis (RA)
T2 - A systematic review and dose-response meta-analysis of randomized controlled trials
AU - Al-Saoodi, Hagir
AU - Kolahdooz, Fariba
AU - Andersen, Jens Rikardt
AU - Jalili, Mahsa
N1 - CURIS 2023 NEXS 169
PY - 2024
Y1 - 2024
N2 - Context: Rheumatoid arthritis is a chronic inflammatory disease that causessynovitis. Vitamin D deficiency is common in rheumatoid arthritis. Objective: This systematic review and meta-analysis investigated whether vitamin D supplementation affects the inflammatory and clinical outcomes in patients with rheumatoid arthritis on the basis of randomized clinical trials. Data Sources: A literature search was performed in the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, MEDLINE, Embase, and Google Scholar for articles published until May 2022. Data Extraction: The studies were selected according to PRISMA guidelines, and the risk of bias was assessed for randomized controlled trials. Data Analysis: A random effects model was used to conduct a meta-analysis, and heterogeneity was assessed using the I2 statistic. Of 464 records, 11 studies were included from 3049 patients. Conclusion: Vitamin D supplementation did not significantly reduce C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), disease activity score in 28 joints (DAS28), or the health assessment questionnaire score; however, the response to supplementation was highly heterogeneous. The pooled analysis showed that vitamin D significantly reduced the pain–visual analogue scale (VAS) weighted mean difference (WMD¼ –1.30, 95% confidence interval [CI] [–2.34, 27], P = .01), DAS28–CRP (WMD = –.58, 95% CI [–.86, –.31], P < .0001), and DAS28–ESR (WMD = –.58, 95% CI [–.86, –.31], P = .0001). Subgroup analysis for vitamin D doses (>100 mg per day versus <100 mg per day) showed that the higher doses had a more significant effect on CRP than the lower doses (P < .05).Conclusions: There was no significant difference between the effect of 2 vitamin D doses on ESR and DAS28. To minimize the high heterogeneity among studies in this meta-analysis, other confounding factors such as baseline vitamin D, age,dietary vitamin D, time of year, sun exposure, drug interaction, effect dosage, and power of study should be examined.
AB - Context: Rheumatoid arthritis is a chronic inflammatory disease that causessynovitis. Vitamin D deficiency is common in rheumatoid arthritis. Objective: This systematic review and meta-analysis investigated whether vitamin D supplementation affects the inflammatory and clinical outcomes in patients with rheumatoid arthritis on the basis of randomized clinical trials. Data Sources: A literature search was performed in the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, MEDLINE, Embase, and Google Scholar for articles published until May 2022. Data Extraction: The studies were selected according to PRISMA guidelines, and the risk of bias was assessed for randomized controlled trials. Data Analysis: A random effects model was used to conduct a meta-analysis, and heterogeneity was assessed using the I2 statistic. Of 464 records, 11 studies were included from 3049 patients. Conclusion: Vitamin D supplementation did not significantly reduce C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), disease activity score in 28 joints (DAS28), or the health assessment questionnaire score; however, the response to supplementation was highly heterogeneous. The pooled analysis showed that vitamin D significantly reduced the pain–visual analogue scale (VAS) weighted mean difference (WMD¼ –1.30, 95% confidence interval [CI] [–2.34, 27], P = .01), DAS28–CRP (WMD = –.58, 95% CI [–.86, –.31], P < .0001), and DAS28–ESR (WMD = –.58, 95% CI [–.86, –.31], P = .0001). Subgroup analysis for vitamin D doses (>100 mg per day versus <100 mg per day) showed that the higher doses had a more significant effect on CRP than the lower doses (P < .05).Conclusions: There was no significant difference between the effect of 2 vitamin D doses on ESR and DAS28. To minimize the high heterogeneity among studies in this meta-analysis, other confounding factors such as baseline vitamin D, age,dietary vitamin D, time of year, sun exposure, drug interaction, effect dosage, and power of study should be examined.
KW - Faculty of Science
KW - Inflammation
KW - Meta-analysis
KW - Rheumatoid arthritis
KW - Systematic review
KW - Vitamin D
U2 - 10.1093/nutrit/nuad083
DO - 10.1093/nutrit/nuad083
M3 - Review
C2 - 37437898
VL - 82
SP - 600
EP - 611
JO - Nutrition Reviews
JF - Nutrition Reviews
SN - 0029-6643
IS - 5
ER -
ID: 357842715