Role of KATP channels in the regulation of rat dura and pia artery diameter
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Role of KATP channels in the regulation of rat dura and pia artery diameter. / Gozalov, A.; Petersen, K.A.; Mortensen, C.; Jansen-Olesen, I.; Klærke, Dan Arne; Olesen, J.
I: Cephalalgia, Bind 25, Nr. 4, 2005, s. 249-260.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Role of KATP channels in the regulation of rat dura and pia artery diameter
AU - Gozalov, A.
AU - Petersen, K.A.
AU - Mortensen, C.
AU - Jansen-Olesen, I.
AU - Klærke, Dan Arne
AU - Olesen, J.
PY - 2005
Y1 - 2005
N2 - The aim of the present study was to examine the effect of K(ATP) channel openers pinacidil and levcromakalim on rat dural and pial arteries as well as their inhibition by glibenclamide. We used an in-vivo genuine closed cranial window model and an in-vitro organ bath. Glibenclamide alone reduced the dural but not the pial artery diameter compared with controls. Intravenous pinacidil and levcromakalim induced dural and middle cerebral artery relaxation that was significantly attenuated by glibenclamide. In conclusion, K(ATP) channel openers induce increasing diameter/relaxation of dural and pial arteries after intravenous infusion in vivo and on isolated arteries in vitro. Furthermore, dural arteries were more sensitive to K(ATP) channel openers than pial arteries.
AB - The aim of the present study was to examine the effect of K(ATP) channel openers pinacidil and levcromakalim on rat dural and pial arteries as well as their inhibition by glibenclamide. We used an in-vivo genuine closed cranial window model and an in-vitro organ bath. Glibenclamide alone reduced the dural but not the pial artery diameter compared with controls. Intravenous pinacidil and levcromakalim induced dural and middle cerebral artery relaxation that was significantly attenuated by glibenclamide. In conclusion, K(ATP) channel openers induce increasing diameter/relaxation of dural and pial arteries after intravenous infusion in vivo and on isolated arteries in vitro. Furthermore, dural arteries were more sensitive to K(ATP) channel openers than pial arteries.
KW - Former LIFE faculty
KW - Dural and pial arteries
KW - glibenclamide
KW - KATP channels
KW - levcromakalim
KW - pinacidil
U2 - 10.1111/j.1468-2982.2004.00848.x
DO - 10.1111/j.1468-2982.2004.00848.x
M3 - Journal article
C2 - 15773822
VL - 25
SP - 249
EP - 260
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
IS - 4
ER -
ID: 7998707