The calcium-sensing receptor and calcimimetics in blood pressure modulation
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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The calcium-sensing receptor and calcimimetics in blood pressure modulation. / Smajilovic, Sanela; Yano, Shozo; Jabbari, Reza; Tfelt-Hansen, Jacob.
I: British Journal of Pharmacology, Bind 164, Nr. 3, 10.2011, s. 884-893.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - The calcium-sensing receptor and calcimimetics in blood pressure modulation
AU - Smajilovic, Sanela
AU - Yano, Shozo
AU - Jabbari, Reza
AU - Tfelt-Hansen, Jacob
N1 - This article is part of a themed issue on Vascular Endothelium in Health and Disease. Keywords: calcium-sensing receptor; G-protein; seven-transmembrane receptor; vascular tone; calcimimetics
PY - 2011/10
Y1 - 2011/10
N2 - Calcium is a crucial second messenger in the cardiovascular system. However, calcium may also be an extracellular first messenger through a G-protein-coupled receptor that senses extracellular concentration (Ca(2+)(o)), the calcium-sensing receptor (CaR). The most prominent physiological function of the CaR is to maintain the extracellular Ca(2+) level in a very tight range by regulating the circulating levels of parathyroid hormone (PTH). This control over PTH and Ca(2+) levels is partially lost in patients suffering from primary and secondary hyperparathyroidism. Allosteric modulators of the CaR (calcimimetics) are the first drugs in their class to become available for clinical use and have been shown to successfully treat certain forms of primary and secondary hyperparathyroidism. In addition, several studies suggest beneficial effects of calcimimetics on cardiovascular risk factors associated with hyperparathyroidism. Although a plethora of studies demonstrated the CaR in heart and blood vessels, exact roles of the receptor in the cardiovascular system still remain to be elucidated. However, several studies point toward a possibility that the CaR might be involved in the regulation of vascular tone. This review will summarize the current knowledge on the possible functions of the CaR and calcimimetics on blood pressure regulation.
AB - Calcium is a crucial second messenger in the cardiovascular system. However, calcium may also be an extracellular first messenger through a G-protein-coupled receptor that senses extracellular concentration (Ca(2+)(o)), the calcium-sensing receptor (CaR). The most prominent physiological function of the CaR is to maintain the extracellular Ca(2+) level in a very tight range by regulating the circulating levels of parathyroid hormone (PTH). This control over PTH and Ca(2+) levels is partially lost in patients suffering from primary and secondary hyperparathyroidism. Allosteric modulators of the CaR (calcimimetics) are the first drugs in their class to become available for clinical use and have been shown to successfully treat certain forms of primary and secondary hyperparathyroidism. In addition, several studies suggest beneficial effects of calcimimetics on cardiovascular risk factors associated with hyperparathyroidism. Although a plethora of studies demonstrated the CaR in heart and blood vessels, exact roles of the receptor in the cardiovascular system still remain to be elucidated. However, several studies point toward a possibility that the CaR might be involved in the regulation of vascular tone. This review will summarize the current knowledge on the possible functions of the CaR and calcimimetics on blood pressure regulation.
KW - Faculty of Health and Medical Sciences
KW - Former Faculty of Pharmaceutical Sciences
U2 - 10.1111/j.1476-5381.2011.01317.x
DO - 10.1111/j.1476-5381.2011.01317.x
M3 - Review
C2 - 21410453
VL - 164
SP - 884
EP - 893
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
SN - 0007-1188
IS - 3
ER -
ID: 38098775