Concise synthesis of new bridged-nicotine analogues
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Concise synthesis of new bridged-nicotine analogues. / Crestey, François; Hooyberghs, Geert ; Kristensen, Jesper Langgaard.
I: Tetrahedron, Bind 68, Nr. 5, 04.02.2012, s. 1417-1421.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Concise synthesis of new bridged-nicotine analogues
AU - Crestey, François
AU - Hooyberghs, Geert
AU - Kristensen, Jesper Langgaard
N1 - Keywords: Pyridine metallation; Bridged-nicotine analogue; Suzukie-Miyaura cross-coupling reaction; Nicotinic acetylcholine receptor; Intramolecular reductive amination
PY - 2012/2/4
Y1 - 2012/2/4
N2 - This study describes a very efficient strategy for the synthesis of two new bridged-nicotine analogues. Starting from either 4- or 3-chloropyridine the desired tricyclic ring systems are accessed in just three steps in 23% and 40% overall yield, respectively.
AB - This study describes a very efficient strategy for the synthesis of two new bridged-nicotine analogues. Starting from either 4- or 3-chloropyridine the desired tricyclic ring systems are accessed in just three steps in 23% and 40% overall yield, respectively.
KW - Former Faculty of Pharmaceutical Sciences
U2 - 10.1016/j.tet.2011.12.029
DO - 10.1016/j.tet.2011.12.029
M3 - Journal article
VL - 68
SP - 1417
EP - 1421
JO - Tetrahedron
JF - Tetrahedron
SN - 0040-4020
IS - 5
ER -
ID: 37426122